Alliston Lab


Selected Publications

1. Bailey KN, Alliston T. At the Crux of Joint Crosstalk: TGFβ Signaling in the Synovial Joint. Curr Rheumatol Rep. 2022 May
DOI: 10.1007/s11926-022-01074-6

2. Kaya S, Schurman CS, Dole NS, Evans DS, Alliston T. Prioritization of Genes Relevant to Bone Fragility Through the Unbiased Integration of Aging Mouse Bone Transcriptomics and Human GWAS Analyses. J Bone Miner Res. 2022 Jan
DOI: 10.1002/jbmr.4516

3. Dole NS, Yoon J, Monteiro DA, Yang J, Mazur CM, Kaya S, Belair CD, Alliston T. Mechanosensitive miR-100 coordinates TGFβ and Wnt signaling in osteocytes during fluid shear stress. The FASEB J. 2021 Sept
DOI: 10.1096/fj.202100930

4. Schurman CS, Verbruggen SW, Alliston T. Disrupted osteocyte connectivity and pericellular fluid flow in bone with aging and defective TGF-β signaling. PNAS. 2021 June
DOI: 10.1073/pnas.2023999118

5. Monteiro DA, Dole NS, Campos JL, Kaya S, Schurman CS, Belair CD, Alliston T. Fluid shear stress generates a unique signaling response by activating multiple TGFβ family type I receptors in osteocytes. The FASEB J. 2021 Feb
DOI: 10.1096/fj.202001998R

6. Bailey KN, Nguyen J, Yee CS, Dole NS, Dang A, Alliston T. Mechanosensitive Control of Articular Cartilage and Subchondral Bone Homeostasis Requires Osteocytic TGFβ Signaling. Arthritis Rheumatol. 2020 Oct
DOI: 10.1002/art.41548

7. Nguyen J, Massoumi R, Alliston T. CYLD, a mechanosensitive deubiquitinase, regulates TGFß signaling in load-induced bone formation. Bone. 2020 Feb;131:115148
DOI: 10.1016/j.bone.2019.115148

8. Mazur CM, Woo JJ, Yee CS, Fields AJ, Acevedo C, Bailey KN, Kaya S, Fowler TW, Lotz JC, Dang A, Kuo AC, Vail TP, Alliston T. Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis. Bone Res. 2019; 7:34
DOI: 10.1038/s41413-019-0070-y

9. Yee CS, Schurman CA, White CR, Alliston T. Investigating Osteocytic Perilacunar/Canalicular Remodeling. Curr Osteoporos Rep. 2019 Aug; 17(4):157-168
DOI: 10.1007/s11914-019-00514-0

10. Acevedo C, Sylvia M, Schaible E, Graham JL, Stanhope KL, Metz LN, Gludovatz B, Schwartz AV, Ritchie RO, Alliston TN, Havel PJ, Fields AJ. Contributions of Material Properties and Structure to Increased Bone Fragility for a Given Bone Mass in the UCD-T2DM Rat Model of Type 2 Diabetes. Curr Osteoporos Rep. J Bone Miner Res. 2018 Feb; 33(6):1066-1075.
DOI: 10.1002/jbmr.3393

11. Dole NS, Mazur CM, Acevedo C, Lopez JP, Monteiro DM, Fowler TW, Gludovatz B, Walsh F, Regan JN, Messina S, Evans DS, Lang TF, Zhang B, Ritchie RO, Mohammad KS, Alliston T. Osteocyte-Intrinsic TGF-β Signaling Regulates Bone Quality through Perilacunar/Canalicular Remodeling. Cell Rep. 2017 Nov;21(9):2585-96.
DOI: 10.1016/celrep2017.10.115

12. Fowler TW, Acevedo C, Mazur CM, Hall-Glenn F, Fields AJ, Bale HA, Ritchie RO, Lotz JC, Vail TP, Alliston T. Glucocorticoid suppression of osteocyte perilacunar remodeling is associated with subchondral bone degeneration in osteonecrosis. Sci. Rep. 2017 Mar;7:44618. 
DOI: 10.1038/srep44618

13. Rys JP, DuFort CC, Monteiro DA, Baird MA, Oses-Prieto JA, Chand S, Burlingame AL, Davidson MW, Alliston T. Discrete spatial organization of TGFβ receptors couples receptor multimerization and signaling to cellular tension. eLife 2015.
DOI: 10.7554/eLife.09300

14. Chen CG, Thuillier D, Chin EN, Alliston T. Chondrocyte-intrinsic Smad3 represses Runx2-inducible matrix metalloproteinase 13 expression to maintain articular cartilage and prevent osteoarthritis. Arthritis Rheum. 2012 Oct;64(10):3278-89.
DOI: 10.1002/art.34566

15. Tang SY, Herber RP, Ho SP, Alliston T. Matrix metalloproteinase-13 is required for osteocytic perilacunar remodeling and maintains bone fracture resistance. J Bone Miner Res. 2012 Sep;27(9):1936-50.
DOI: 10.1002/jbmr.1646

16. Allen JL, Cooke ME, Alliston T. ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation. Mol Biol Cell. 2012 Sep;23(18):3731-42.
DOI: 10.1091/mbc.E12-03-0172

17. Chang JL, Brauer DS, Johnson J, Chen CG, Akil O, Balooch G, Humphrey MB, Chin EN, Porter AE, Butcher K, Ritchie RO,Schneider RA, Lalwani A, Derynck R, Marshall GW, Marshall SJ, Lustig L, Alliston T. Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-β and Runx2 in bone is required for hearing. EMBO Rep. 2010 Oct;11(10):765-71
DOI: 10.1038/embor.2010.135

18. Balooch G, Balooch M, Nalla RK, Schilling S, Filvaroff EH, Marshall GW, Marshall SJ, Ritchie RO, Derynck R, Alliston T. TGFβ regulates the mechanical properties and composition of bone matrix. Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18813-8.
DOI: 10.1073/pnas.0507417102

Comprehensive Publication List

Link to Tamara Alliston on PubMed