Claire Acevedo, PhD

Education
Doctor of Philosophy, Fatigue and Fracture Mechanics, Swiss Federal Institute of Technology in Lausanne (EPFL), 2011

Biography
After completing my Ph.D. training at the Swiss Federal Institute of Technology in Lausanne (EPFL) investigating the fatigue response of metallic joints using an experimental multiscale approach (i.e. studying microstructural mechanisms influencing fracture and fatigue resistance), it became clear to me that this approach would have great potential in biological materials with a complex hierarchical structure such as bone. Then, I moved to the US with a Swiss SNF postdoctoral fellowship to tackle these new challenges in Rob Ritchie's group at UC Berkeley and Lawrence Berkeley National Laboratory (LBNL). My work using synchrotron radiation instruments at the Advanced Light Source at LBNL provided a foundation for understanding mechanisms by which the transfer of strain between collagen and mineral and ultimately the bone’s intrinsic resistance to fracture can be impaired by disease or treatment.

In January 2015, fascinated by the potential role of osteocyte activity under cyclic loading, I joined the Alliston lab. In the Alliston lab, my research focuses on understanding the role that osteocyte-mediated remodeling plays in affecting bone quality through mineralization, collagen deformation, and lacunar geometry changes using cutting-edge synchrotron experiments. The finding of this novel role for osteocytes may elucidate mechanisms of skeletal disease and novel therapies targeting osteocytes.

Research Interests
• Stress and fatigue fracture
• Skeletal biomechanics
• Bone quality and bone fragility
• Multiscale approach - X-ray synchrotron
• Collagen and mineral deformation

Favorite Bone
Tibia

Publications

• Most recent publication:
C. Acevedo, H. Bale, B. Gludovatz, A. Wat, S. Y. Tang, M. Wang, B. Busse, E. A. Zimmermann, E. Schaible, M. R. Allen, D. B. Burr, and R. O. Ritchie. Alendronate treatment alters bone tissues at multiple structural levels in healthy canine cortical bone. Bone, vol. 81, Dec. 2015, pp. 352-363. DOI: 10.1016/j.bone.2015.08.002

• Complete list of publications:
Google Scholar Profile

Contact
Claire.ScholtesAcevedo [at] ucsf.edu